Statistics is widely used in all fields of science and many business fields because software package programs have developed by following theoretical developments. In an environment dominated by uncertainty, it is extremely important to ensure that statistics, which are used as a tool for making the right decision, are learned and comprehended both theoretically and practically. In our opinion, the most important feature of this book is that it has been prepared in such a way as to support the distance education system and self-learning effort, which has become widespread with the Covid-19 epidemic, both theoretically and practically. Therefore, in the book; first, the theoretical explanation about each section was made comprehensively, interpreted in detail with solved examples, and then the examples related to the subjects were applied using Excel, SPSS, Matlab or R software packages. Thus, it is aimed to minimize the need for teachers and classroom environment as in traditional formal education. With this book, it is expected that the deficiency in the self-learning, application and interpretation of statistics will be eliminated.